Drug intelligence / Profile preview

Flavoxine

Development stage
Unknown
Lead developer
Next Pharmaceuticals
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Flavoxine is a patented, natural dietary supplement ingredient developed by Next Pharmaceuticals designed to support cardiovascular health. It is a proprietary combination of two botanical extracts: a proprietary extract of *Phellodendron amurense* bark and a patented extract of *Citrus sinensis* (orange) peel standardized for polymethoxylated flavones (PMFs). Clinical research indicates that Flavoxine significantly improves lipid profiles by reducing LDL-cholesterol and triglycerides while increasing HDL-cholesterol. Furthermore, it has demonstrated the ability to lower blood pressure, fasting blood glucose, and C-reactive protein (CRP), a key marker of systemic inflammation. It is marketed as a nutraceutical ingredient for inclusion in heart health formulations rather than as a prescription pharmaceutical drug.

Brand names
Flavoxine
Other names
Phellodendron amurense and Citrus sinensis extract
02

Targets

mAChR (Muscarinic acetylcholine receptors)

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