Drug intelligence / Profile preview

flecainide

Development stage
Approved
Lead developer
Boehringer Ingelheim
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

Flecainide is a class Ic antiarrhythmic medication used to prevent and treat abnormally fast heart rates, including paroxysmal supraventricular tachycardia (PSVT), paroxysmal atrial fibrillation/flutter (PAF), and sustained ventricular tachycardia. It works primarily by blocking fast inward sodium channels in cardiac cells, which slows intracardiac conduction and prolongs the refractory period of the heart. Flecainide also inhibits delayed rectifier potassium channels and ryanodine receptor 2, further stabilizing cardiac electrical activity. The drug is indicated for patients without structural heart disease who experience disabling arrhythmias[1][3][4][5][6]. Flecainide was first approved for medical use in the United States in 1985[5].

Brand names
Tambocor
Other names
flecainide acetate
02

Targets

KCNB1 (Potassium channel subfamily V member 2 (Kv2.1))KCNH2 (Voltage-gated potassium channel subfamily H member 2)RYR2 (Ryanodine receptor 2)SCN5A (Sodium channel protein type 5 subunit alpha)SCN4A (Voltage-gated sodium channel protein type 4 subunit alpha)

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