fleroxacin

Fleroxacin is a third-generation fluoroquinolone antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria. It acts by strongly inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination. This inhibition leads to disruption of bacterial DNA processes and ultimately cell death. The drug is well absorbed orally, has high bioavailability, distributes widely in tissues (with higher concentrations in bile, nasal secretions, seminal fluid, lung tissue), and has a relatively long elimination half-life (9–12 hours), allowing once-daily dosing. It is primarily indicated for the treatment of uncomplicated cystitis in women, acute uncomplicated pyelonephritis, gonorrhea, bacterial enteritis (including traveler's diarrhea), and respiratory tract infections such as exacerbations of chronic bronchitis[1][2][3][4][5].

Brand names

QuinodisMegalocinMegalone

Other names

FleroxicinFleroxacineFleroxacinoFleroxacinum