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Flixocort
- Development stage
- Phase 4
- Lead developer
- Healthcare Pharmaceuticals
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Inhalation
01
Overview
Flixocort is an inhaled corticosteroid (ICS) containing fluticasone propionate, developed and manufactured by Medicair. It functions as a potent agonist of the glucocorticoid receptor (NR3C1), leading to the suppression of inflammatory genes and the activation of anti-inflammatory genes within the airway. This mechanism reduces mucosal edema, decreases inflammatory cell infiltration, and alleviates airway hyperresponsiveness. Flixocort is indicated for the maintenance treatment of asthma and the management of symptoms in chronic obstructive pulmonary disease (COPD) and allergic airway inflammation.
- Brand names
- Flixocort
- Other names
- fluticasone propionate
02
Targets
PLA2G4A (Cytosolic phospholipase A2 alpha)GR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)PR (Progesterone receptor)
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