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Fliz-1 silencing vector
- Development stage
- Preclinical
- Lead developer
- Villanova University
- Modality
- Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Parenteral
01
Overview
Fliz-1 silencing vector is an experimental gene therapy agent designed to knock down the expression of the zinc finger CCCH domain-containing protein 8 (ZC3H8, also known as Fliz-1). Developed by researchers at Villanova University, the vector targets ZC3H8, which acts as a transcriptional repressor of the GATA3 promoter. In preclinical models of breast cancer, silencing of Fliz-1 relieves the repression of GATA-3 and estrogen receptor alpha, thereby restoring sensitivity to endocrine therapies such as tamoxifen and reducing tumor growth.
- Other names
- Fliz1 silencing vectorFliz-1 silencing vectorFliz 1 silencing vectorZC3H8 silencing vectorZC-3H8 silencing vectorZC 3H8 silencing vector
02
Targets
ZC3H8 (Zinc finger CCCH domain-containing protein 8)GATA3 (GATA Binding Protein 3)ESR1 (ERα)
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