Drug intelligence / Profile preview

flos albiziae

Development stage
Unknown
Administration
Oral, Topical
01

Overview

Flos albiziae refers to the dried flowers of Albizia julibrissin, commonly known as the silk tree or mimosa. In Traditional Chinese Medicine (TCM), it is called 合欢花 (He Huan Hua) and is primarily used for its calming and mood-uplifting properties. The main pharmacological actions include anxiolytic, antidepressant, sedative, antioxidant, anti-inflammatory, and neuroprotective effects. These are attributed to bioactive compounds such as saponins (notably Julibroside C1), flavonoids (like quercetin and kaempferol), triterpenoids, lignans, sterols, and alkaloids[1][2][3][4]. Flos albiziae acts by modulating serotonergic and dopaminergic pathways in the brain to alleviate anxiety and depression[3]. It is also traditionally used for insomnia, irritability due to emotional distress or qi stagnation in TCM theory[4], poor memory[5], trauma-related swelling or pain[4], skin conditions like boils or abscesses when applied topically[2][5], and as a mild tonic. Modern research supports its use for stress-related disorders but clinical evidence remains limited.

Other names
Albizia julibrissin flowerHe Huan HuaSilk tree flowerMimosa flower合欢花
02

Targets

HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))

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