Drug intelligence / Profile preview

flowering quince extract

Development stage
Unknown
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

**Flowering quince extract** is a botanical extract derived from the fruits, leaves, and sometimes other parts (flowers, seeds) of various Chaenomeles species, especially *Chaenomeles speciosa*, *Chaenomeles japonica*, and *Chaenomeles sinensis*. It is rich in **polyphenols, flavonoids, triterpenoids (notably oleanolic and ursolic acid), phenolic acids, and organic acids**. The extract demonstrates multiple **bioactivities** in vitro and in animal studies, including **antioxidant, anti-inflammatory, antimicrobial, immunoregulatory, hepatoprotective, antinociceptive, antihyperlipidemic, antihyperglycemic, antitumor, and potentially anti-Parkinson activities**[2][3][4][5][7]. Mechanisms include modulation of **COX-2, MMP-9, and NF-kB signaling pathways**, and the suppression of pro-inflammatory cytokines (e.g., IL-1β, TNF-α, IL-6)[5]. Flowering quince extract is used in traditional medicine (East Asia and beyond) for conditions such as **rheumatism, dysentery, enteritis, and for liver protection**. In modern use, it is employed as an **ingredient in dietary supplements and skincare formulations**, valued for its **antioxidant, anti-inflammatory, and skin-protective** effects[6].

Other names
Chaenomeles speciosa extractJapanese quince extractChaenomeles japonica extractChaenomeles sinensis extractChinese quince extract
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)NOS2 (Nitric Oxide Synthase 2)MMP2 (Matrix metalloproteinase-2)MMP9 (Matrix metalloproteinase-9)RELA (Nuclear Factor Kappa B Subunit p65)

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