floxuridine

Floxuridine is an antimetabolite chemotherapy drug primarily used for the palliative management of liver metastases from gastrointestinal tract cancers, especially colorectal cancer. It is a pyrimidine analog (specifically a deoxyuridine derivative) that acts by inhibiting DNA synthesis in rapidly dividing cells. After administration, floxuridine is rapidly converted to 5-fluorouracil (5-FU), which inhibits thymidylate synthase and disrupts the incorporation of thymidine nucleotides into DNA, thereby blocking cell division during the S-phase of the cell cycle. Floxuridine is typically administered via continuous intra-arterial infusion directly to the hepatic artery supplying blood to liver tumors.

Brand names

FUDR

Other names

5-fluoro-2'-deoxyuridineFUDR