Drug intelligence / Profile preview

floxuridine + dexamethasone + heparin + oxaliplatin + capecitabine + leucovorin + fluorouracil

Development stage
Preclinical
Lead developer
Roche
Modality
Small Molecules
Administration
Intravenous, Oral, Subcutaneous, Intra-arterial
01

Overview

This is a complex combination chemotherapy regimen that includes multiple cytotoxic agents and supportive medications. The core components include: - **Oxaliplatin**: A platinum-based cytotoxic agent that forms DNA adducts, inhibiting DNA replication and transcription - **Fluorouracil (5-FU)**: A pyrimidine analog that inhibits thymidylate synthase, disrupting DNA synthesis - **Capecitabine**: An oral prodrug of 5-FU that is converted to the active drug in tumor tissues - **Leucovorin (folinic acid)**: A reduced folate that enhances the efficacy of 5-FU by stabilizing the binding of 5-FU to thymidylate synthase - **Floxuridine**: A fluorinated pyrimidine nucleoside that is metabolized to 5-FU - **Dexamethasone**: A corticosteroid used to prevent nausea and vomiting associated with chemotherapy - **Heparin**: An anticoagulant that may be included to prevent thrombotic complications This combination may be used in advanced colorectal cancer treatment protocols, potentially in specific clinical contexts requiring intensive therapy.

02

Targets

ATIII (Antithrombin III)GR (Glucocorticoid receptor)TS (Thymidylate synthase)

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