Drug intelligence / Profile preview

Fluarix-AS01B

Development stage
Approved
Lead developer
GSK
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

**Fluarix-AS01B** was an investigational GSK seasonal influenza vaccine candidate consisting of the licensed Fluarix inactivated influenza vaccine antigen formulation adjuvanted with the proprietary **AS01B** liposomal adjuvant system. AS01B contains 3-O-desacyl-4′-monophosphoryl lipid A and QS-21, which enhance innate immune activation and antigen-specific cellular and humoral immune responses. It was evaluated as a single intramuscular dose in adults aged 65 years and older to improve influenza-vaccine immune responses affected by immunosenescence. The candidate was studied in a completed Phase 2 trial and was not marketed as a distinct product.

Other names
Fluarix + AS01B
02

Targets

HA (Hemagglutinin)TLR4 (Toll-like receptor 4)

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