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This entry refers to a specific collection of vaccines evaluated in a longitudinal cohort study led by the University of Melbourne (NCT03275311). The study investigates the immunological consequences of repeated annual influenza vaccination and the impact of SARS-CoV-2 infection or vaccination on healthcare workers. The influenza component includes several quadrivalent vaccines: Fluarix Tetra (GSK), Vaxigrip Tetra (Sanofi), Fluquadri (Sanofi), Fluad Quad (adjuvanted, CSL Seqirus), Afluria Quad (CSL Seqirus), and Flucelvax Quad (cell-culture derived, CSL Seqirus). The COVID-19 component involves the administration of Comirnaty (Pfizer/BioNTech) or Vaxzevria (AstraZeneca). These vaccines function by inducing active immunity against specific viral antigens—hemagglutinin for influenza and the spike protein for SARS-CoV-2—to elicit protective antibody and cellular immune responses.
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