Fluclorolone acetonide

Fluclorolone acetonide is a potent synthetic glucocorticoid corticosteroid primarily used for its anti-inflammatory and immunosuppressive properties in dermatological applications. It exerts its therapeutic effects by penetrating cellular membranes and binding to specific glucocorticoid receptors in the cytoplasm. This drug-receptor complex then translocates to the nucleus, where it modulates gene transcription, leading to the suppression of pro-inflammatory molecules such as cytokines, prostaglandins, and leukotrienes, and reducing immune cell activity. It also stabilizes lysosomal membranes, preventing the release of enzymes that contribute to tissue destruction, thereby reducing swelling, redness, and pain associated with inflammatory skin conditions.

Brand names

TopilarCutanitTopicon

Other names

flucloronide