flucloxacillin

Flucloxacillin is a narrow-spectrum beta-lactam antibiotic of the penicillin class, primarily used to treat infections caused by susceptible Gram-positive bacteria, especially those producing beta-lactamase (penicillinase). It is commonly prescribed for skin and soft tissue infections, bone and joint infections (such as osteomyelitis), ear infections in children, respiratory tract infections, endocarditis, and for surgical prophylaxis against Staphylococcus aureus. Flucloxacillin works by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs), thereby preventing cross-linking of peptidoglycan chains essential for cell wall strength and integrity. This action leads to bacterial cell lysis and death. It is resistant to degradation by most staphylococcal beta-lactamases due to its isoxazolyl side chain. Flucloxacillin can be administered orally or parenterally (intravenous or intramuscular injection)[1][2][4].

Brand names

FlucFlucilFlucillinFluxinFlxzenFucil

Other names

floxacillinflucloxacilinaflucloxacillineflucloxacillinum