flucloxacillin + tobramycin

Flucloxacillin + tobramycin is a combination of two antibiotics used primarily for the prevention and treatment of serious bacterial infections, particularly in hospital settings such as cardiac surgery. Flucloxacillin is a narrow-spectrum beta-lactam antibiotic (penicillin class) that acts by inhibiting bacterial cell wall synthesis, mainly targeting Gram-positive organisms including Staphylococcus aureus (excluding MRSA). Tobramycin is an aminoglycoside antibiotic that binds to the 30S ribosomal subunit, inhibiting protein synthesis and leading to bacterial cell death; it has strong activity against Gram-negative bacteria such as Pseudomonas aeruginosa. The combination provides broad-spectrum coverage against both Gram-positive and Gram-negative pathogens, making it suitable for prophylaxis or empirical therapy in high-risk surgical procedures or severe infections[1][4].