fludarabine + cyclophosphamide + rituximab + ibrutinib

FCR + ibrutinib is an investigational combination chemoimmunotherapy regimen being evaluated for the treatment of chronic lymphocytic leukemia (CLL). The regimen combines the standard FCR backbone—comprising fludarabine (a purine analog), cyclophosphamide (an alkylating agent), and rituximab (an anti-CD20 monoclonal antibody)—with ibrutinib, a small molecule inhibitor of Bruton's tyrosine kinase (BTK). In clinical studies, such as the Phase 2 trial sponsored by the Institute of Hematology & Blood Diseases Hospital in China (NCT03980002), the regimen is sometimes referred to as the 'HAMBURGER regimen' and involves alternating cycles of FCR with ibrutinib monotherapy. The combination aims to achieve deeper remissions and improve minimal residual disease (MRD) negativity rates by combining cytotoxic chemotherapy with targeted inhibition of B-cell receptor signaling.

Brand names

ImbruvicaRituxanMabThera

Other names

FCR-Iibrutinib-FCRFCR plus ibrutinibibrutinib + FCR