fludarabine phosphate

Fludarabel is a brand name for fludarabine phosphate, a fluorinated nucleotide analog of the antiviral agent vidarabine (ara-A). Developed by the Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus in collaboration with the Institute of Microbiology of the National Academy of Sciences of Belarus and Pharmtechnology, Fludarabel is used as an antineoplastic antimetabolite. It is rapidly dephosphorylated in vivo to 2-fluoro-ara-A, which is then intracellularly phosphorylated to its active triphosphate form, 2-fluoro-ara-ATP. This active metabolite inhibits DNA synthesis by targeting DNA polymerase and ribonucleotide reductase, and incorporates into DNA to cause chain termination. Fludarabel is primarily indicated for the treatment of B-cell chronic lymphocytic leukemia (CLL) and other hematological malignancies such as indolent non-Hodgkin's lymphomas.

Brand names

FludaraFludarabelOforta

Other names

2-fluoro-ara-A2-fluoro-ara-AMPFAMPfludarabinefludarabine phosphate