fludeoxyglucose f 18

Fludeoxyglucose F 18 is a radiopharmaceutical agent used primarily as a diagnostic imaging tracer in positron emission tomography (PET) scans. It is a glucose analog labeled with the radioactive isotope fluorine-18. After intravenous administration, it accumulates in cells with high rates of glucose metabolism—such as cancer cells, certain brain regions, and cardiac tissue—because it is transported into cells by glucose transporter proteins and phosphorylated by hexokinase to FDG-6-phosphate. Unlike normal glucose metabolites, FDG-6-phosphate cannot be further metabolized or exit the cell until dephosphorylation occurs; thus it becomes trapped within metabolically active tissues. This property allows PET imaging to visualize areas of increased or decreased metabolic activity for diagnosing cancer, heart disease (myocardial viability), and neurological disorders such as epilepsy[1][3][4][8]. Fludeoxyglucose F 18 was developed for use in nuclear medicine and molecular imaging.

Brand names

Fludeoxyglucose F 18 Injection

Other names

fluorodeoxyglucose f 18fluorodeoxyglucose (18f)fdg