flumedroxone

Flumedroxone is a synthetic steroidal progestin of the pregnane class, structurally characterized as a 6α-(trifluoromethyl) derivative of 17α-hydroxyprogesterone. It has been investigated primarily as an oral antimigraine agent, especially in women whose migraines are exacerbated around menstruation. Flumedroxone exhibits weak progestogenic activity and lacks significant estrogenic, antiestrogenic, androgenic, anabolic, or glucocorticoid effects. Its mechanism is presumed to involve modulation of hormonal pathways related to menstrual migraine but does not extend to other major hormone receptor activities. The acetate ester form (flumedroxone acetate) was marketed under brand names such as Demigran and Leomigran for migraine prophylaxis[2][3][7].

Other names

6α-(trifluoromethyl)-17α-hydroxyprogesterone