Drug intelligence / Profile preview

flunisolide

Development stage
Approved
Lead developer
Bayer HealthCare Pharmaceuticals
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Inhalation, Intranasal
01

Overview

Flunisolide is a synthetic corticosteroid used primarily as an inhaled or intranasal medication for the prophylactic treatment of asthma and the management of allergic rhinitis. It acts as a glucocorticoid receptor agonist, exerting potent anti-inflammatory effects by inhibiting multiple inflammatory cytokines and mediators. This results in decreased swelling and irritation in the airways or nasal passages, leading to relief from symptoms such as wheezing, coughing (in asthma), sneezing, runny nose, congestion (in allergic rhinitis), and postnasal drip. Flunisolide is not intended for acute symptom relief but rather for regular maintenance therapy[1][2][3][4][5]. The developer was Schering-Plough, and the current manufacturer is Organon (a subsidiary of Merck & Co.).

Brand names
AeroBidNasalideNasarelAerospan
Other names
flunisolide hemihydrateflunisolide inhalation aerosolAerospan
02

Targets

GR (Glucocorticoid receptor)

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