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Drug intelligence / Profile preview
fluocinolone
- Development stage
- Approved
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Topical, Otic, Ophthalmic, Intravitreal
01
Overview
Fluocinolone is a synthetic corticosteroid used primarily as a topical medication to treat various inflammatory and pruritic (itchy) skin conditions, including eczema, psoriasis, and atopic dermatitis. It works by activating the glucocorticoid receptor in cells, which leads to the induction of proteins that inhibit phospholipase A2. This action reduces the release of arachidonic acid and subsequently decreases the synthesis of pro-inflammatory mediators such as prostaglandins and leukotrienes. The result is reduced swelling, redness, itching, and discomfort in affected areas. Fluocinolone is available in several formulations including cream, ointment, solution, oil, shampoo for scalp use, and sometimes as an ear drop or ophthalmic implant for other indications[1][3][5][6].
- Brand names
- SynalarCapexDerma-Smoothe/FSFluonidFluotrexXilapak KitFluocet
- Other names
- fluocinolone topical
02
Targets
ESRRA (Estrogen-related receptor alpha)ESRRB (Estrogen-related receptor beta)ESRRG (Estrogen-related receptor gamma)GR (Glucocorticoid receptor)SMO (Smoothened)
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