fluocinolone acetonide

Fluocinolone acetonide is a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties. In the context of Alimera Sciences, it is formulated as Iluvien, a non-erodible intravitreal insert designed to provide sustained release of the drug for up to 36 months. The mechanism involves binding to the glucocorticoid receptor, which modulates gene expression to inhibit the production of inflammatory mediators and reduce vascular permeability. While primarily approved for diabetic macular edema (DME), Alimera conducted the Phase 2 FAVOR study to evaluate its safety and efficacy in patients with macular edema secondary to retinal vein occlusion (RVO).

Brand names

Iluvien

Other names

fluocinolonefluocinolone acetonide intravitreal insert