fluocinolone acetonide + hydroquinone + tretinoin

**Fluocinolone acetonide + hydroquinone + tretinoin** is a prescription fixed-dose topical triple-combination cream containing fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%. Fluocinolone acetonide is a topical corticosteroid that reduces local inflammation and irritation; hydroquinone reduces melanin production through inhibition of tyrosinase activity; and tretinoin is a retinoid that activates retinoic acid receptors, promotes epidermal turnover, and enhances depigmenting activity. The marketed product Tri-Luma is approved in the United States for short-term treatment of moderate-to-severe facial melasma alongside sun avoidance and sunscreen use. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a35fa709-5eb5-4429-b38f-f1e0019bf0ee))

Brand names

Tri-Luma

Other names

fluocinolone acetonide, hydroquinone, and tretinoinfluocinolone acetonide/hydroquinone/tretinoin