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fluorescein-conjugated wisteria floribunda lectin
- Development stage
- Unknown
- Lead developer
- University of Oxford
- Administration
- Topical
01
Overview
Fluorescein-conjugated wisteria floribunda lectin is an investigational fluorescent imaging agent developed by the University of Oxford for the detection of colorectal dysplasia, polyps, and cancer. It consists of a plant-derived lectin from *Wisteria floribunda* (WFL or WFA) chemically linked to the fluorescent dye fluorescein. The agent works by binding specifically to N-acetylgalactosamine (GalNAc)-containing glycan structures that are differentially expressed on the surface of abnormal colorectal tissues compared to healthy mucosa. During endoscopy or surgery, the agent is applied topically to the colon; subsequent illumination with a specific wavelength of light causes the bound lectin to fluoresce, allowing clinicians to identify and delineate dysplastic or malignant lesions in real-time.
- Other names
- fluorescein-conjugated wisteria floribunda lectinWFL-fluoresceinWFA-fluoresceinfluorescent lectin
02
Targets
Tn (Tn antigen)ASGPR (Asialoglycoprotein Receptor 1)
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