Drug intelligence / Profile preview

fluoride, triclosan, amino acid

Development stage
Discontinued
Lead developer
Colgate-Palmolive
Modality
Small Molecules
Administration
Topical
01

Overview

This is a combination of active ingredients used in oral care products, particularly toothpastes. The combination includes fluoride (typically as sodium fluoride or amine fluoride) for cavity prevention, triclosan as an antimicrobial agent, and amino acids (such as arginine or glycine) that help stabilize the formulation and enhance efficacy. Fluoride works by strengthening tooth enamel and preventing dental caries. Triclosan acts as a broad-spectrum antimicrobial that disrupts bacterial cytoplasmic membranes, reducing plaque and gingivitis. The amino acid component helps stabilize the formulation and may enhance the delivery of active ingredients into dental biofilm.

Brand names
Colgate Total
Other names
fluoride, triclosan, amino acidarginine + fluoride + triclosan
02

Targets

InhA

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