fluorine-18 arachidonic acid

Fluorine-18 arachidonic acid is a radiolabeled analog of the polyunsaturated fatty acid arachidonic acid, developed as a positron emission tomography (PET) imaging agent. It serves as a metabolic tracer to study lipid signaling and metabolism, particularly the activity of phospholipase A2 (PLA2) enzymes, which release arachidonic acid from membrane phospholipids. In the context of oncology, specifically advanced prostate cancer, its uptake is used to visualize metabolic reprogramming driven by oncogenes like MYC and epigenetic regulators like KMT2A. The tracer is also utilized in neuroimaging to investigate neuroinflammation and brain signaling, where arachidonic acid metabolism is a key component of the inflammatory response.

Other names

fluorine-18 labeled arachidonic acidfluorine18 labeled arachidonic acidfluorine 18 labeled arachidonic acid[18F]arachidonic acid18F-labeled arachidonic acid