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fluorine F 18 2-PMPA
- Development stage
- Phase 1
- Lead developer
- Bayer
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
BAY1075553 (fluorine F 18 2-PMPA) is a radiolabeled small molecule PET imaging agent developed for the detection of prostate cancer. It acts as an inhibitor of prostate-specific membrane antigen (PSMA), a cell surface protein highly expressed in prostate cancer cells. The compound is labeled with fluorine-18 and used as a tracer in positron emission tomography/computed tomography (PET/CT) to visualize PSMA-expressing tumors. Preclinical and phase I clinical studies have shown that BAY1075553 accumulates in PSMA-positive tissues and is generally safe and well tolerated. However, its diagnostic performance may be limited by early renal excretion and non-specific uptake in degenerative bone lesions[1][5][7].
- Other names
- (2RS,4S)-2-[18F]Fluoro-4-phosphonomethyl-pentanedioic acid
02
Targets
PSMA (Prostate-specific membrane antigen)
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