fluorine F 18-BMS-986229

fluorine F 18-BMS-986229 is a radiopharmaceutical diagnostic agent consisting of a macrocyclic peptide (BMS-986229) labeled with the positron-emitting isotope fluorine‑18. It is designed as a high-affinity, selective ligand for programmed death-ligand 1 (PD-L1), enabling noninvasive imaging of PD-L1 expression in tumors using positron emission tomography (PET). The tracer demonstrates rapid clearance from non–PD-L1-expressing tissues and strong, specific binding to PD-L1, allowing for assessment of spatial heterogeneity in PD-L1 expression. It was developed using BMS‑986189 as the starting scaffold and optimized for radiolabeling and imaging performance. The primary clinical application is in oncology diagnostics, particularly to guide immunotherapy decisions by visualizing PD-L1 status in cancers such as gastroesophageal adenocarcinoma[1][2][4][6].

Other names

PD-L1 Macrocyclic Peptide PET TracerPD-L-1 Macrocyclic Peptide PET TracerPD-L 1 Macrocyclic Peptide PET Tracer