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fluorine F 18 W372
- Development stage
- Preclinical
- Lead developer
- SMI
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Fluorine F 18 W372 is a radiotracer composed of the compound W372 labeled with the radioisotope fluorine-18. It is designed for use as a positron emission tomography (PET) imaging agent with potential activity for imaging amyloid-beta (Aβ) peptide deposits in the brain. This makes it potentially useful in detecting and evaluating amyloid plaques associated with Alzheimer's disease and related neurodegenerative conditions. The mechanism of action involves binding to amyloid-beta aggregates, allowing visualization via PET scanning due to the radioactive decay of fluorine-18[1][3]. The molecular formula is C14H9FN4OS[2].
- Other names
- W-372 F-18W372 F-18W 372 F-18(18F)W372
02
Targets
Amyloid-beta aggregate (N-terminal epitope)
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