fluoro-willardiine

Fluoro-Willardiine is a synthetic analog of willardiine and a potent, selective agonist of ionotropic glutamate receptors, specifically the AMPA receptor subtypes GluA1 and GluA2. It acts as an orthosteric agonist at these receptors with high affinity and selectivity over other glutamate receptor subtypes such as kainate or NMDA receptors. Fluoro-Willardiine is primarily used in research to study excitatory neurotransmission mediated by AMPA-type glutamate receptors in the central nervous system. It is not approved for clinical use and has no known therapeutic indications[1][3][9].

Other names

(alphaS)-alpha-Amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid3-(5-fluorouracil-1-yl)-L-alanine(S)-2-amino-3-(5-fluoro-2,4-dioxopyrimidin-1-yl)propanoic acid140187–23–1