fluoroquinolone + antibiotics-Egyptian Biomedical Research Network

fluoroquinolone + antibiotics-Egyptian Biomedical Research Network refers to the standard antibiotic prophylaxis regimen used as a comparator in a randomized clinical trial conducted by the Egyptian Biomedical Research Network. The regimen consists of an intravenous fluoroquinolone administered one hour prior to flexible ureteroscopy (fURS), followed by a 24-hour course of oral antibiotics postoperatively. Fluoroquinolones are a class of small molecule antibiotics that exert their bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This specific protocol was evaluated for its efficacy in preventing post-procedural urinary tract infections in patients undergoing surgical management for kidney or ureteral stones, compared against an enhanced prophylaxis protocol involving pre-operative urine cultures and specialized ureteral access sheaths.

Other names

Standard antibiotic prophylaxis in fURSStandard antibiotic prophylaxis-Egyptian Biomedical Research Network