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Fluorouracil + carboplatin or cisplatin
- Development stage
- Unknown
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules
- Administration
- Intravenous, Topical
01
Overview
Fluorouracil + carboplatin or cisplatin refers to a combination chemotherapy regimen commonly used for the treatment of various cancers, including advanced head and neck cancer and advanced gastric (stomach) cancer. Fluorouracil is a pyrimidine analog antimetabolite that inhibits thymidylate synthase, disrupting DNA synthesis and function, leading to cell death. Carboplatin and cisplatin are platinum-based alkylating agents that form DNA crosslinks, inhibiting DNA replication and transcription, ultimately triggering apoptosis in rapidly dividing cells. These combinations are typically administered intravenously in cycles as part of multi-agent chemotherapy protocols[1][3][7][8].
- Brand names
- ActikerallCaracEfudexFluoroplexTolak
- Other names
- 5-fluorouracil
02
Targets
TS (Thymidylate synthase)
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