Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
fluorouracil + irinotecan + leucovorin + oxaliplatin
- Development stage
- Unknown
- Lead developer
- Sanofi
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
FOLFIRINOX is a combination chemotherapy regimen consisting of four drugs: fluorouracil (5-FU), irinotecan, leucovorin (folinic acid), and oxaliplatin. It is primarily used as a first-line treatment for advanced or metastatic pancreatic adenocarcinoma in patients with good performance status. The regimen may also be used in the adjuvant or neoadjuvant setting for pancreatic cancer and has been studied in colorectal cancer. - **Mechanism of Action:** - Fluorouracil is an antimetabolite that inhibits thymidylate synthase, disrupting DNA synthesis. - Irinotecan is a topoisomerase I inhibitor that prevents DNA unwinding and replication. - Leucovorin enhances the binding of fluorouracil to thymidylate synthase, increasing its efficacy. - Oxaliplatin forms platinum-DNA adducts leading to apoptosis by inhibiting DNA replication and transcription. The combination targets multiple pathways involved in tumor cell proliferation and survival[1][2][3][4][7].
- Brand names
- FOLFIRINOX
- Other names
- fluorouracil, irinotecan, leucovorin, oxaliplatin combination5-FU/irinotecan/leucovorin/oxaliplatinFOLFIRINOX regimen
02
Targets
DNATOP1 (DNA Topoisomerase I)TS (Thymidylate synthase)
Beyond the preview
Go deeper on fluorouracil + irinotecan + leucovorin + oxaliplatin.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on fluorouracil + irinotecan + leucovorin + oxaliplatin.