fluorouracil + platinum

Fluorouracil + platinum refers to a chemotherapy combination regimen that includes the antimetabolite 5-fluorouracil (5-FU) and a platinum-based compound (most commonly cisplatin or carboplatin). This combination is used in the treatment of various cancers, including gastrointestinal cancers such as metastatic small bowel adenocarcinoma and anal cancer. - **Mechanism of Action:** - 5-fluorouracil inhibits thymidylate synthase, disrupting DNA synthesis and repair in rapidly dividing cells. - Platinum compounds (e.g., cisplatin) form DNA crosslinks that prevent DNA replication and transcription, leading to cell death. The combination exploits synergistic cytotoxic effects on tumor cells by targeting different aspects of DNA metabolism and integrity[1][2][3]. - **Administration:** Both drugs are administered intravenously; regimens may vary but often involve cycles with continuous infusion of 5-FU over several days combined with intermittent dosing of the platinum agent[2][3]. - **Indications:** Used for several solid tumors including metastatic small bowel adenocarcinoma[1], anal cancer[3], esophageal squamous cell carcinoma[5], head and neck cancers, among others.

Other names

5-fluorouracil + platinum5-FU + platinumcisplatin + fluorouracilFUP regimen