flupentixol

Flupentixol is a first-generation (typical) antipsychotic of the thioxanthene class. It is primarily used for the maintenance therapy of chronic schizophrenia, especially in patients with poor compliance or frequent relapses, and can be administered as a long-acting injection or oral tablet. At lower doses, it is also prescribed for depression with or without anxiety. The drug acts mainly as an antagonist at dopamine D1 and D2 receptors with equal affinities and has additional antagonistic activity at alpha-1 adrenoceptors and serotonin 5-HT2A/2C receptors. Its antipsychotic effects are attributed to dopamine receptor blockade in the brain's mesolimbic and mesocortical pathways; antidepressant effects may relate to serotonergic antagonism. Flupentixol also exhibits weak anticholinergic and adrenergic properties, mild sedative actions, anxiolytic effects, antiemetic activity, and can cause extrapyramidal side effects at higher doses[1][4][5][6][8]. **Developers:** Lundbeck **Primary Indication:** Schizophrenia

Brand names

FluanxolDepixolJexit

Other names

flupenthixol