Drug intelligence / Profile preview

flupirtine + interferon beta-1b

Development stage: Preclinical
Lead developer: Theriva Biologics
Modality: Recombinant Proteins and Enzymes, Small Molecules
Administration: Oral, Subcutaneous

Overview

A combination of flupirtine, a non-opioid analgesic with neuroprotective properties, and interferon beta-1b, an immunomodulatory therapy for multiple sclerosis. This combination aims to provide both neuroprotection and immunomodulation for patients with multiple sclerosis, particularly those with optic neuritis. Research suggests that the combination may improve visual function better than either agent alone.

Targets

IFNAR2 (Interferon alpha/beta receptor subunit 2)KCNQ (Potassium voltage-gated channel subfamily Q (Kv7))IFNAR (Immune system modulation via type I interferon receptor)NMDAR (Glutamate receptor ionotropic, NMDA)GABRR (GABA-A receptor subunit rho)

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