fluprostenol

Fluprostenol is a synthetic analogue of prostaglandin F2alpha and an organofluorine compound in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. It acts as a potent and highly selective agonist of the Prostaglandin F2-alpha receptor (FP receptor). Fluprostenol has roles as an antiglaucoma drug, antihypertensive agent, female contraceptive drug, and abortifacient. Its primary mechanism involves activation of the FP receptor leading to phospholipase C activation and increased intracellular calcium via Gq protein signaling[1][4][6]. Ophthalmic solutions of its isopropyl ester prodrug (travoprost) are used for reducing intraocular pressure in open-angle glaucoma and ocular hypertension[1][7]. In veterinary medicine (notably in mares), it is used for its luteolytic effect to control estrus timing[5].

Other names

travoprost acid16-m-trifluoromethylphenoxy tetranor Prostaglandin F2α