flurandrenolide

Flurandrenolide is a synthetic fluorinated corticosteroid used topically for its anti-inflammatory, antipruritic, and vasoconstrictive properties. It acts as an agonist at the glucocorticoid receptor, leading to the induction of phospholipase A2 inhibitory proteins, known as lipocortins. These proteins control the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes, by inhibiting the release of their common precursor, arachidonic acid. Flurandrenolide is indicated for the relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, including eczematous dermatitis, psoriasis, and various forms of dermatitis. Originally developed by Eli Lilly under the brand name Cordran, it is available in several formulations including ointments, creams, lotions, and a unique medicated tape for sustained topical delivery.

Brand names

CordranCordran SPCordran Tape

Other names

flurandrenolone6alpha-fluoro-16alpha-hydroxyhydrocortisone 16,17-acetonide