Flurandrenolide acetate

Flurandrenolide acetate is a synthetic fluorinated corticosteroid primarily used topically to alleviate inflammatory and pruritic manifestations of various corticosteroid-responsive dermatoses. Its therapeutic action stems from its ability to bind to specific cytoplasmic glucocorticoid receptors within target cells. This binding initiates a cascade of events, including the translocation of the receptor-drug complex into the cell nucleus, where it modulates gene expression. This leads to anti-inflammatory effects by stabilizing cellular and lysosomal membranes, inhibiting phospholipase A2, and consequently reducing the biosynthesis of prostaglandins and leukotrienes. Additionally, it exhibits antipruritic effects by stabilizing mast cells and vasoconstrictive properties, which help reduce erythema and edema in inflamed tissues. It is available in various topical formulations such as creams, ointments, lotions, and tapes, with varying potencies depending on the formulation.

Brand names

CordranCordran SPCordran TapeNolixHaelanDrenisonDrocortSermakaHaldrone-FAlondra-F

Other names

FludroxycortideFlurandrenoloneFluorandrenoloneFludroxicortidaFludroxycortidum