flurbiprofen axetil + dexmedetomidine

This is a combination of two drugs—flurbiprofen axetil, a nonsteroidal anti-inflammatory drug (NSAID) formulated for intravenous use, and dexmedetomidine, a highly selective alpha-2 adrenergic receptor agonist. The combination is used perioperatively to enhance postoperative analgesia and sedation. Flurbiprofen axetil provides analgesic and anti-inflammatory effects by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing prostaglandin synthesis. Dexmedetomidine acts centrally to provide sedation, anxiolysis, sympatholysis, and additional analgesia by activating presynaptic alpha-2 adrenergic receptors in the brainstem. Clinical studies have shown that this combination improves pain control after surgery compared to either agent alone; it also stabilizes hemodynamics during anesthesia induction/extubation, reduces stress response, enhances immune function (e.g., higher T/B lymphocyte counts), lowers inflammatory cytokines (TNF-α/IL-6), promotes wound healing, reduces agitation/restlessness postoperatively, and may help preserve cognitive function[1][2][4][5][7].

Other names

flurbiprofen axetil and dexmedetomidinedexmedetomidine plus flurbiprofen axetil