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fluspidine

Development stage: Unknown
Lead developer: Helmholtz-Zentrum Dresden-Rossendorf
Modality: Alpha Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Beta Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules
Administration: Intravenous

Overview

Fluspidine is a spirocyclic piperidine derivative developed as a positron emission tomography (PET) tracer for the imaging of sigma-1 (σ1) receptors. Both (S)- and (R)-enantiomers labeled with fluorine-18, known as (S)-[18F]fluspidine and (R)-[18F]fluspidine, have been evaluated in humans for PET imaging. Fluspidine exhibits very high affinity and selectivity for the sigma-1 receptor over the sigma-2 receptor, making it valuable for non-invasive quantification of sigma-1 receptors in the brain, which are implicated in neuropsychiatric and neurodegenerative disorders[4][8].

Other names: (S)-[18F]fluspidine(R)-[18F]fluspidine[18F]fluspidine

Targets

SIGMAR1 (Sigma non-opioid intracellular receptor 1)

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