flutamide

Flutamide is a nonsteroidal antiandrogen used primarily in the treatment of prostate cancer. It acts as a selective antagonist of the androgen receptor by competing with androgens such as testosterone and dihydrotestosterone for binding to these receptors in tissues like the prostate gland. This blockade prevents androgen-driven growth and proliferation of prostate cancer cells. It is also used off-label for other androgen-dependent conditions such as polycystic ovarian syndrome (PCOS), acne vulgaris and hirsutism. The drug is typically administered alongside a luteinizing hormone-releasing hormone agonist to enhance efficacy in advanced or metastatic prostate cancer[1][2][3][4][5][7]. First described in 1967 and introduced into medical use in 1983 (US approval 1989), it has largely been replaced by newer agents due to safety concerns—most notably hepatotoxicity—and more convenient dosing regimens[7].

Brand names

EulexinCebatrolCytomidDrogenilEtaconilFlucinomFlumidFlutacanFlutamidFlutamidaFlutaminFlutanFlutaplexFlutasinFugerelProfamidSebatrol

Other names

flutamidum (Latin)flutamid (German)flutamida (Spanish)