Drug intelligence / Profile preview

flutemetamol

Development stage
Approved
Lead developer
GE Healthcare
Modality
Alpha Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Beta Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous
01

Overview

Flutemetamol is a radiopharmaceutical diagnostic agent used in positron emission tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's disease or other causes of cognitive decline. After intravenous administration, it crosses the blood-brain barrier and binds selectively to β-amyloid plaques. The fluorine-18 isotope emits positrons detectable by PET scanning, allowing visualization of amyloid plaque distribution in the brain. Flutemetamol is not a therapeutic agent but an adjunctive diagnostic tool. It was developed and is manufactured by GE Healthcare[1][2][3][5][6].

Brand names
Vizamyl
Other names
flutemetamol F 18 injectionfluorine-18-flutemetamolfluorine18-flutemetamolfluorine 18-flutemetamol
02

Targets

Aβ (Amyloid-beta peptides and aggregates)

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