Drug intelligence / Profile preview

fluticasone furoate

Development stage
Approved
Lead developer
GSK
Modality
Small Molecules
Administration
Intranasal, Inhalation
01

Overview

Fluticasone furoate is a synthetic, trifluorinated corticosteroid with potent anti-inflammatory activity. It is a glucocorticoid receptor agonist that modulates the expression of genes involved in the inflammatory response, leading to the inhibition of multiple cell types (such as mast cells, eosinophils, and lymphocytes) and the release of inflammatory mediators like histamine, cytokines, and leukotrienes. AVAFLUT is a generic formulation of fluticasone furoate developed and marketed by OSL Pharma in Bangladesh, primarily indicated for the management of symptoms associated with seasonal and perennial allergic rhinitis. It is also available in inhalation formats for the maintenance treatment of asthma.

Brand names
AVAFLUTAvamysVeramystArnuity Ellipta
Other names
fluticasone furoate
02

Targets

ER (Estrogen receptor)AR (Adrenergic receptors)PR (Progesterone receptor)GR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)

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