Drug intelligence / Profile preview

fluticasone furoate + umeclidinium

Development stage
Unknown
Lead developer
GSK
Modality
Small Molecules
Administration
Inhalation
01

Overview

Fluticasone furoate + umeclidinium is a fixed-dose combination of two inhaled medications used for the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Fluticasone furoate is an inhaled corticosteroid (ICS) that reduces inflammation in the airways, while umeclidinium is a long-acting muscarinic antagonist (LAMA) that acts as a bronchodilator by blocking muscarinic receptors in airway smooth muscle, leading to relaxation and improved airflow. This combination may be used alone or as part of triple therapy with vilanterol for COPD management[5][8]. The primary indication is long-term maintenance treatment to improve breathing and reduce exacerbations in COPD.

Other names
umeclidinium bromide + fluticasone furoateumeclidinium + fluticasone furoate
02

Targets

GR (Glucocorticoid receptor)CHRM3 (M3)

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