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fluticasone propionate
- Development stage
- Approved
- Lead developer
- GSK
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Inhalation, Intranasal, Topical
01
Overview
Fluticasone propionate is a synthetic glucocorticoid steroid medication used primarily for its anti-inflammatory effects. It is available in various formulations including inhalers (for asthma and chronic obstructive pulmonary disease), nasal sprays (for allergic rhinitis and nasal polyps), and topical creams (for skin conditions such as eczema and psoriasis). The drug works by activating glucocorticoid receptors to suppress inflammation through multiple pathways. It was first patented in 1980 and approved for medical use in 1990. Fluticasone propionate is widely prescribed globally and is available as both branded and generic products[4][5].
- Brand names
- FloventFlonaseAdvairAirduoAirduo RespiclickAller-floArmonairBeserCutivateDymistaFluticareTicanaseWixelaXhance
- Other names
- fluticasone propionate inhalation aerosolfluticasone propionate HFA
02
Targets
MR (Mineralocorticoid receptor)GR (Glucocorticoid receptor)PLA2G4A (Cytosolic phospholipase A2 alpha)PR (Progesterone receptor)Kv1 (Voltage-gated potassium channel subfamily A)
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