Drug intelligence / Profile preview

fluticasone propionate + ginkgo biloba extract

Development stage
Unknown
Lead developer
GSK
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Inhalation, Intranasal, Topical, Oral
01

Overview

This is a combination product containing fluticasone propionate, a synthetic glucocorticoid corticosteroid, and ginkgo biloba extract, an herbal supplement derived from the leaves of the Ginkgo biloba tree. Fluticasone propionate acts as an anti-inflammatory agent by binding to the glucocorticoid receptor and modulating gene expression to suppress inflammatory mediators. It is commonly used for asthma, allergic rhinitis, and various inflammatory skin conditions[2]. Ginkgo biloba extract contains terpene lactones (such as ginkgolides) and flavonoids with antioxidant and vasoactive properties; it has been studied for cognitive enhancement, neuroprotection, cardiovascular health, and other uses[1]. The combination may be intended to provide both anti-inflammatory effects (from fluticasone) and potential neuroprotective or circulatory benefits (from ginkgo), though there are no widely recognized approved indications for this specific combination.

02

Targets

PTAFR (Platelet-activating factor receptor)GR (Glucocorticoid receptor)

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