fluvoxamine + trazodone

Fluvoxamine + trazodone is a combination of two antidepressant medications, each with distinct mechanisms of action. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) primarily used to treat obsessive-compulsive disorder (OCD), while trazodone is classified as a serotonin antagonist and reuptake inhibitor (SARI) mainly indicated for major depressive disorder and also used off-label for insomnia and behavioral symptoms in dementia. Both drugs increase serotonergic activity in the central nervous system but through different pharmacological targets. The combination has been reported in case studies to be effective for certain neuropsychiatric symptoms such as pica in Alzheimer's disease, though it carries significant risk of drug-drug interaction, particularly serotonin syndrome due to additive serotonergic effects[2][3][1].