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FMT + low-fermentable fiber
- Development stage
- Unknown
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral, Rectal, Nasoduodenal
01
Overview
Fecal microbiota transplantation (FMT) + low-fermentable fiber is a combination therapy involving the administration of fecal material from a healthy donor to a recipient, followed by supplementation with dietary fibers that are minimally fermented by gut bacteria. The goal is to restore or modulate the gut microbiome and enhance engraftment of beneficial microbes. This approach has been studied primarily in metabolic diseases such as severe obesity and metabolic syndrome, where it has shown improvements in insulin sensitivity and incretin hormone production. The mechanism involves both direct modulation of the gut microbial community via FMT and support for specific microbial taxa through targeted dietary intervention with low-fermentable fibers, which may facilitate better engraftment of donor microbes and improved host metabolic outcomes[1][2][5].
- Other names
- fecal microbiota transplantation plus low-fermentable fiberFMT and low fermentable fiber supplementation
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