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FMT capsules
- Development stage
- Unknown
- Lead developer
- Massachusetts General Hospital
- Modality
- Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
FMT capsules (Massachusetts General Hospital) is an investigational live biotherapeutic product consisting of oral, frozen capsules containing the complete fecal microbiota derived from healthy, lean donors. Developed by Massachusetts General Hospital in collaboration with Seres Therapeutics, the therapy is designed to modulate the gut microbiome of individuals with obesity and insulin resistance to improve systemic metabolism. The intervention was evaluated in the Phase 1/2 FMT-TRIM trial (NCT02530385), which demonstrated successful engraftment of donor bacteria in the recipients' intestines that persisted for at least 12 weeks. However, the study found no clinically significant improvements in insulin sensitivity, body weight, or other metabolic parameters compared to placebo.
- Other names
- FMT-TRIMFecal Microbiota Transplantation capsulesfrozen encapsulated inoculum
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