folate-NC

**folate-NC** is an experimental **folate-targeted miR-34a RNA therapeutic** in which a miR-34a mimic is incorporated into a folate-decorated nanocarrier, described in the literature as a folate-conjugated or folate-nanolipoplex formulation. The therapeutic concept is to deliver tumor-suppressive miR-34a selectively to **folate receptor alpha expressing cancer cells**, thereby restoring miR-34a activity and downregulating oncogenic stemness and survival pathways. Published preclinical work indicates anti-tumor activity in folate receptor alpha positive breast, ovarian, cervical, and lung cancer models, while showing limited activity in prostate cancer because of low target receptor expression. The agent appears to be a research-stage academic therapeutic rather than a commercial product, with no evidence in the provided context of regulatory approval or late-stage clinical development.

Other names

folate-conjugated miR-34afolate-miR-34afolate-miR34afolate-miR 34afolate-nanolipoplex entrapping miR-34a